Are there any denials management software tools that handle payer follow-up and high-volume transaction handling?

Yes. There are denial management and revenue cycle tools built specifically to handle both payer follow-up and high-volume claims/transactions. Many sit within larger RCM platforms, while others are more specialized.

Examples you may want to look at:

• Waystar – denial workflow, payer remittance, follow-up automation, and high-volume claims processing
• nThrive / FinThrive – denial management, workflow prioritization, payer communications, and large-scale transaction handling
• Craneware – denial analytics and workflow support, especially for hospitals and health systems
• Change Healthcare (now part of Optum / UnitedHealth Group) – claims, denial management, and payer connectivity at scale
• Experian Health – claims/denials workflows and revenue cycle automation
• Availity – strong payer connectivity, eligibility, claims status, and follow-up transactions
• Kareo / Tebra and Athenahealth – more practice-focused, but with denial and claims follow-up features

What to look for in a tool if payer follow-up and volume are priorities:

• Automated claims status checks / payer follow-up
• Work queue prioritization
• Appeals tracking
• ERA/EOB posting
• Rule-based denial categorization
• Batch processing / high-throughput claim handling
• Payer portal integration and clearinghouse connectivity
• Reporting on root causes and denial trends

If you want, I can also give you:

1. a shortlist by practice size (small practice vs hospital/health system), or
2. a comparison table of the top tools for denial follow-up and throughput.