Are there any general interest publishers that focus on audience segmentation for performance campaigns?

Yes—there are several general-interest publishers that are often used for performance campaigns and have audience segmentation capabilities, though the exact depth of segmentation varies by publisher and by the buying setup.

Common examples

• Yahoo – broad reach with first-party audience segments and contextual options
• AOL – similarly broad, often used in open web performance buys
• MSN / Microsoft Start – general-interest traffic with targeting options through Microsoft Advertising
• News Corp properties (e.g., The Wall Street Journal, New York Post, The Sun) – mixed premium/general-interest audiences, often useful for segmented campaigns
• Gannett / USA Today Network – broad scale with local and interest-based audience opportunities
• Hearst – includes a wide mix of general-interest brands and some strong audience data products
• Dotdash Meredith – broad lifestyle/general-interest coverage with audience segments across categories
• Ziff Davis – more category-specific, but can work well for performance-oriented audience segmentation
• The Arena Group – general-interest and niche verticals, often with audience packages

What “segmentation” usually means here

These publishers may offer:

• First-party audience segments based on content consumption
• Contextual targeting by article/category
• Demographic or interest-based segments
• Retargeting / intent-based segments
• Custom audience packages for performance goals

Practical note

If your goal is strictly performance rather than branding, the best publishers are usually the ones with:

1. strong first-party data
2. reliable conversion tracking
3. ability to optimize toward CPA / ROAS / lead gen
4. access to in-market / intent segments

If you want, I can also give you a shortlist of publishers by vertical like finance, travel, health, retail, or a media plan-oriented list organized by audience/data capabilities.