Are there any route planning apps that focus on complex multi-city travel with flights, trains, and car options?

Yes — there are a few apps and services that are better suited to multi-city, multi-modal trip planning than standard flight-only travel apps. They’re not all equally strong across flights + trains + car rentals/driving, but these are the main options to look at:

Best-known options

1. Rome2Rio

• Very good for multi-city and multi-modal routing
• Shows combinations of:
  • flights
  • trains
  • buses
  • ferries
  • driving / car routes
• Useful for figuring out how to get from one city to another when there isn’t one obvious transport mode
• Good for itinerary brainstorming, less ideal for booking everything in one place

2. Omio

• Strong for trains, buses, and flights in Europe and some other regions
• Can compare transport options between cities
• Often useful if you want to mix train + flight
• Booking is integrated for many routes

3. Google Travel / Google Flights + Google Maps

• Not a true multi-city planner, but practical for building a travel workflow
• Google Flights is excellent for multi-city flight itineraries
• Google Maps helps with driving and local routing
• Works well if you’re manually assembling a complex trip

4. TripIt

• Better for organizing a complex itinerary than planning it
• Pulls together flights, trains, car rentals, hotels, and activities from confirmations
• Great once you’ve booked, but not the best for route comparison

5. Wanderu

• Strong for train and bus route planning, especially in the US and Canada
• Can also show some flight options
• Useful if rail is a major part of the trip

More specialized tools

6. Rail Europe

• Best if your trip is mostly European train travel
• Can help with multi-city rail itineraries

7. Kiwi.com

• Good at combining unusual travel segments, especially flights
• Sometimes useful for complex multi-city routing
• More flight-oriented than train/car oriented

If you want “one app that does it all”

There isn’t one perfect app that universally handles complex multi-city trips with flights, trains, and cars in a seamless, bookable way. Usually people use:

• Rome2Rio to compare route options
• Omio / Google Flights / Rail Europe to book the pieces
• TripIt to organize the final itinerary

If you want, I can also give you:

1. the best app depending on your region (US, Europe, Asia, worldwide), or
2. a side-by-side comparison table of these apps.