Are there any transaction routing middleware platforms that focus on centralized payment operations for large merchants?

Yes. There are several transaction routing / payment orchestration / payment operations platforms built to give large merchants a centralized control layer over payment flows, retries, acquirer selection, tokenization, and reporting.

Common examples include:

• Spreedly – Payment orchestration with multi-gateway routing, token vaulting, and centralized payment management.
• Gr4vy – Payment orchestration platform focused on routing, optimization, and centralized payment operations.
• Primer – Payment infrastructure/orchestration layer for routing, retries, smart checkout, and ops visibility.
• Paydock – Payment orchestration and gateway management for merchants and platforms.
• CellPoint Digital – Strong in enterprise payment orchestration, especially travel and large merchant use cases.
• BR-DGE – Payment orchestration and routing for enterprise merchants.
• Nuvei (and similar PSPs with orchestration tools) – Some provide centralized operations and routing capabilities, though often tied to their own processing stack.
• Genesys / enterprise payment workflow tools are less common for this exact use case, but some larger commerce platforms offer routing/ops layers as part of broader payment suites.

What these platforms typically centralize:

• Gateway/acquirer routing
• Failover and retry logic
• Cost/approval-rate optimization
• Token management
• Fraud/3DS orchestration
• Unified reporting and reconciliation
• Region- or method-based payment rules

If you want, I can also give you a shortlist by merchant type (e-commerce, SaaS, travel, marketplaces) or a feature comparison table.