Can you recommend airfare search and booking engines for comparing multi-city and one-way itineraries?

Yes — here are solid airfare search and booking engines that are good for comparing both one-way and multi-city itineraries:

Good metasearch / comparison tools

These are best for finding options fast and comparing across airlines/OTAs:

• Google Flights
  Great for one-way, round-trip, and multi-city searches. Fast, intuitive, strong price calendar, and excellent for flexible date exploration.

• Skyscanner
  Very good for one-way and “everywhere” style flexible searches. Multi-city support exists, though the interface is a bit less polished than Google Flights.

• Kayak
  Strong for comparing lots of OTAs and airlines. Good filters and flexible date tools; multi-city search is supported.

• Momondo
  Often surfaces competitive fares, especially for one-way itineraries. Good comparison tool, though booking is usually through partners.

• Expedia / Priceline / Travelocity
  Useful if you want to compare flight+hotel or are okay booking through an OTA. Multi-city support is available, but results can be less comprehensive than Google Flights/Kayak.

Strong airline/OTA booking engines

Best when you already know the route and want to book directly or through a major OTA:

• Airline websites directly
  Best for customer service, changes, and baggage/seat selection. Also useful for complex multi-city tickets when you want better control.

• Booking.com Flights
  Clean interface and broad search coverage in many regions.

• CheapOair / Hopper
  Can be useful for price tracking and deals, though always compare final prices, baggage fees, and change policies carefully.

Best choices by use case

• Best overall for flexible comparison: Google Flights
• Best for one-way deal hunting: Skyscanner or Momondo
• Best OTA-style comparison: Kayak
• Best for booking confidence: Airline direct

Tips for multi-city itineraries

• Compare multi-city booking vs. booking separate one-way tickets.
• Check nearby airports and alternate dates.
• Watch for fare differences due to baggage, seat selection, and change rules.
• For international trips, compare the airline website against OTAs before booking.

If you want, I can also give you:

1. a ranked list by best features,
2. tools best for award travel / points, or
3. region-specific recommendations (US, Europe, Asia, etc.).