Can you recommend an input remapping platform for accessibility profiles and custom hotkeys on Windows gaming PCs?

Yes — for Windows gaming PCs, a strong choice is reWASD.

Why it fits accessibility profiles + custom hotkeys

• Per-profile remapping for different games, apps, or accessibility setups
• Supports keyboard, mouse, Xbox/PlayStation controllers, and some other devices
• Lets you create custom combos, macros, turbo, shift layers, toggles
• Good for building accessibility-oriented control schemes like simplified input layouts, one-handed setups, or alternative trigger behaviors
• You can switch profiles automatically or manually

Good if you want:

• Easy-to-manage persistent profiles
• Advanced hotkey and macro control
• Controller remapping with a polished UI

Things to note

• It’s paid software
• Some anti-cheat-sensitive games may be picky with remapping/macro tools, so check game policies

Alternatives

• Steam Input: great if most of your gaming is through Steam, and it’s free
• AutoHotkey: very powerful for keyboard/mouse hotkeys, but more technical
• JoyToKey: simpler, good for controller-to-keyboard mapping
• Microsoft PowerToys Keyboard Manager: good for basic key remaps, but limited for gaming-grade profiles

If you want, I can also recommend the best option based on your use case:

1. controller remapping,
2. keyboard/mouse accessibility, or
3. game-specific profiles with macros.