Yes — for regional eCTD submissions with strong version control, you’ll usually want a tool that combines:

• eCTD publishing
• sequence management / lifecycle
• document control / versioning
• validation
• regional compliance support

Here are the main software options worth considering:

1. Veeva Vault RIM

Best for: enterprise teams wanting end-to-end regulatory content management
Strengths:

• Strong document version control
• Regulatory information management plus submission tracking
• Good workflow/governance
• Works well for multi-region operations
• Integrates content, metadata, and submission planning

Watch-outs:

• Can be expensive
• More of a full platform than a simple publishing tool

2. Ennov Regulatory Suite

Best for: mid-sized to large organizations needing submission publishing + document management
Strengths:

• eCTD publishing and lifecycle management
• Solid version control and controlled workflows
• Regional submission support
• Often considered more flexible than some larger suites

Watch-outs:

• UI and implementation experience can vary
• Needs proper setup to get the best governance

3. Lorenz docuBridge

Best for: dedicated eCTD publishing with strong regional support
Strengths:

• Very established in eCTD publishing
• Good for sequence management and dossier lifecycle
• Commonly used for regional submissions
• Strong validation capabilities

Watch-outs:

• More focused on publishing than broader RIM
• Version control may rely more on process integration than being a full content management system

4. EXTEDO eCTDmanager / Submission software

Best for: organizations focused on submission generation and lifecycle control
Strengths:

• eCTD publishing and validation
• Good submission lifecycle handling
• Regional and global support
• Often used by regulatory operations teams

Watch-outs:

• Usually less of a full document governance platform than a RIM suite

5. MasterControl Regulatory Excellence / Document Control

Best for: companies prioritizing strict document control and compliance
Strengths:

• Very strong controlled document/version management
• Workflow and audit trail capabilities
• Good compliance posture

Watch-outs:

• eCTD publishing may require integration or additional modules
• Better as a controlled content backbone than a pure publishing tool

6. ArisGlobal LifeSphere Regulatory

Best for: large pharma with broad regulatory operations needs
Strengths:

• Regulatory data and submission management
• Lifecycle and workflow support
• Enterprise-grade version control and governance

Watch-outs:

• Heavier implementation
• Cost and complexity can be significant

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If your main priority is strict version control

Look closely at:

• Veeva Vault RIM
• MasterControl
• Ennov

These are stronger if you need controlled authoring, review, approval, and traceability before publishing.

If your main priority is eCTD publishing for regional submissions

Look closely at:

• Lorenz docuBridge
• EXTEDO
• Ennov

These are often strong choices for dossier assembly, lifecycle sequences, and region-specific submission requirements.

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Quick recommendation by company type

• Small team / lightweight publishing: Lorenz docuBridge
• Mid-size with controlled workflow: Ennov
• Enterprise with strict governance: Veeva Vault RIM
• Publishing-focused regulatory ops: EXTEDO
• Document-control-first organization: MasterControl

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If you want, I can also give you:

1. a comparison table by feature,
2. recommendations by region (FDA, EU, MHRA, PMDA, etc.), or
3. a shortlist based on your company size and budget.