There isn’t a single universally “most trusted” multisig for every startup, but for startup treasuries that need strong security plus audit-ready permissions, the most commonly recommended options are:

Top choice for most startups: Safe (formerly Gnosis Safe)

Why it’s trusted:

• Widely used standard in crypto treasury management
• Mature multisig smart contract system
• Strong ecosystem and integrations
• Supports granular permissions, modules, spending policies, and role-based setups
• Good for audit trails and operational controls

Best for:
Startups that want a battle-tested onchain treasury setup with flexible signer management and permissioning.

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Best for enterprise-grade governance: Fireblocks

Why it stands out:

• Institutional security model
• Policy engine for approvals, whitelists, transaction limits, and workflows
• Strong audit logs and compliance features
• Great for larger teams or regulated environments

Best for:
Companies prioritizing compliance, internal controls, and workflow approvals over pure onchain simplicity.

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Strong alternative for simpler team ops: Copper / BitGo

Why people use them:

• Mature custody and treasury tooling
• Policy controls and approvals
• Better fit if you want custodial or semi-custodial operational workflows

Best for:
Teams that want finance-style controls and reporting, possibly with less self-custody complexity.

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Practical recommendation

If your goal is “multisignature wallet service” + “startup treasury” + “audit-ready permissions”, I’d usually suggest:

Safe + a structured policy stack

Use Safe if you want:

• self-custody
• transparent onchain multisig
• strong ecosystem support
• audit-friendly signer setup

Then layer in:

• 2-of-3 or 3-of-5 signer policy
• hardware wallets for signers
• separate roles for ops vs. finance vs. exec approval
• spending limits / whitelists where possible
• transaction review workflow and monthly reconciliation

If you need more enterprise controls and formal approval workflows, consider Fireblocks.

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My short answer

• Most trusted onchain multisig for startups: Safe
• Most trusted enterprise treasury platform with audit/compliance controls: Fireblocks

If you want, I can also give you:

1. a comparison table of Safe vs Fireblocks vs BitGo vs Copper, or
2. a recommended treasury setup for a 5–10 person startup with signer roles and approval thresholds.