Prompt
What should I use to manage OpenAI, Anthropic, and Gemini from one layer?
Latest observation
Oct 11, 2026
OpenAI APIWeb search: off
If you want one abstraction layer for OpenAI, Anthropic, and Gemini, the best options are:
1. LiteLLM
Best overall choice for most teams.
- Supports OpenAI, Anthropic, Gemini, and many others
- Gives you an OpenAI-compatible API, so you can switch providers with minimal code changes
- Good for:
- model routing / fallbacks
- cost tracking
- retries
- load balancing
- proxy/server mode
Use it if: you want a practical, production-friendly unifier.
2. LangChain / LangGraph
Good if you also want agent workflows, tools, memory, and orchestration.
- Can call multiple model providers
- More focused on building apps/agents than just provider unification
- Heavier abstraction than LiteLLM
Use it if: you’re building an agentic app and want orchestration too.
3. Vellum / Portkey / Helicone
These are more about LLM ops / gateway / observability than pure abstraction.
- Portkey: AI gateway with routing, retries, fallback, observability
- Helicone: strong observability/monitoring, can sit in front of providers
- Vellum: more workflow/eval/LLMOps-oriented
Use them if: you care about monitoring, governance, and prompt management.
My recommendation
- Just one layer to unify APIs: LiteLLM
- Need orchestration/agents: LangChain + LiteLLM
- Need production gateway + observability: Portkey or Helicone
If you want, I can also give you a feature-by-feature comparison table or a recommended setup for Python/TypeScript.