Which audio enhancement software supports channel separation and accurate sample rate handling?

If you mean software for audio enhancement/restoration, the key features you’re asking about are usually called:

• channel separation: ability to process left/right channels independently or preserve stereo imaging
• accurate sample-rate handling: proper resampling and no unwanted pitch/time artifacts

A few well-regarded options that support these well are:

1. iZotope RX

   • Excellent for restoration/enhancement
   • Good stereo/channel handling
   • Accurate sample-rate conversion through its engine and export options

2. Adobe Audition

   • Supports separate channel processing and stereo editing
   • Handles sample rates correctly in multitrack and waveform modes

3. Acon Digital Restoration Suite / Acoustica

   • Strong channel-aware processing
   • Good sample-rate support and clean resampling

4. Steinberg SpectraLayers

   • Advanced channel and spectral editing
   • Proper sample-rate handling, especially in professional workflows

If you’re asking about a specific type of “channel separation” like vocal/instrument separation, that’s different from stereo channel separation. In that case, tools like iZotope RX Music Rebalance, Demucs-based tools, or LALAL.AI are more relevant.

If you want, I can recommend the best option based on your exact use case:

• restoration/noise reduction
• stereo channel processing
• vocal separation
• mastering / resampling accuracy