Which genomic analysis software supports large reference datasets and versioned annotations for clinical variant review?

Software commonly used for this purpose includes Integrated Genomics Viewer (IGV) and VarSeq.

If you mean a platform specifically known for large reference datasets and versioned annotations in clinical variant review, VarSeq by Golden Helix is a strong match. It is designed for clinical genomics workflows and supports:

• large annotation/reference databases
• annotation version tracking
• variant filtering and review
• clinical reporting workflows

If you want, I can also list a few alternatives by category:

• open-source
• enterprise clinical
• cloud-based interpretation platforms