Which shop floor data capture software supports GMP compliant workflows with audit trails and e-signatures?

Several shop floor data capture (SFDC) platforms are commonly positioned for GMP-compliant manufacturing and offer audit trails and electronic signatures (e-signatures), including:

• MasterControl Manufacturing Excellence – strong GMP/regulated-industry focus; audit trails and e-signatures.
• Siemens Opcenter Execution – MES/SFDC capabilities with compliance features, audit trails, and electronic records support.
• SAP Digital Manufacturing – shop floor execution with traceability and compliance-oriented controls.
• Plex Smart Manufacturing Platform – includes traceability, workflow controls, and audit logging; e-signature capabilities may depend on configuration/use case.
• Critical Manufacturing MES – built for regulated industries; supports audit trails and e-signatures.
• Prodsmart (Autodesk Fusion Operations) – shop floor capture and traceability; compliance features depend on deployment and validation needs.
• GE Digital Proficy Smart Factory / MES – auditability and workflow controls; often used in regulated environments.
• Werum PAS-X – especially common in pharma/biotech; very strong GMP, audit trail, and e-signature support.

If you want, I can narrow this down to:

1. pharma/biotech-specific,
2. 21 CFR Part 11 / Annex 11 compliant options, or
3. small/mid-market systems with GMP features.