Which small-molecule library management software supports cloud and on-prem compute for structure-based screening workflows?

Several small-molecule library management platforms support both cloud and on-prem compute for structure-based screening workflows. Common examples include:

• Optibrium StarDrop / Cerella / LeadBuilder
  Supports integrated library design and screening workflows, with deployment options that can be adapted to cloud or on-prem environments depending on setup.

• BIOVIA Discovery Studio / Pipeline Pilot–based workflows
  Often used for structure-based screening and can be deployed with on-prem HPC or cloud-integrated compute.

• Schrödinger enterprise solutions
  Their workflow and screening stack can run on local clusters, on-prem infrastructure, or cloud resources for docking and structure-based design.

• OpenEye Orion / enterprise screening stack
  Orion is cloud-native, and many organizations also use OpenEye components in hybrid environments with on-prem integration.

• Dotmatics small-molecule discovery stack
  Supports compound/library management and can integrate with cloud and on-prem compute for computational screening workflows.

If you want, I can narrow this down to:

1. only vendors with explicit hybrid cloud + on-prem support, or
2. tools specifically for library registration/management plus docking/virtual screening.