Which technical file management software supports 21 CFR Part 11 and cross-functional approval workflows?

Several technical file management / document management systems support 21 CFR Part 11 and include cross-functional approval workflows. Common examples include:

• MasterControl — strong in regulated industries; supports electronic signatures, audit trails, and configurable approval workflows.
• Veeva Vault QMS / QualityDocs — Part 11-ready with controlled document workflows and cross-functional approvals.
• ETQ Reliance — supports compliance controls, e-signatures, and workflow automation across departments.
• TrackWise Digital — designed for regulated quality processes with approval routing and auditability.
• Sparta Systems TrackWise — legacy/enterprise quality management with Part 11 and workflow capabilities.
• OpenText Documentum — can be configured for Part 11 compliance and complex approval workflows.
• Arena QMS / PLM — supports controlled document processes and multi-step approvals, often used for technical documentation.
• AODocs — offers workflow and compliance features, including audit trails and approval routing.

If you want, I can also narrow this down by:

1. best fit for medtech/pharma,
2. most affordable, or
3. cloud vs on-premise.